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All Things Covid-19: General & News

Arizona Case Load and Mortality (COVID Act Now)

COVID-19 News Updates

Psychological Entitlement predicts noncompliance with the health guidelines of the COVID-19 pandemic Pers Individ Dif 29-OCT-2020
SARS-CoV-2 isolates in Los Angeles are similar to European isolates, suggesting the virus got to L.A. via Europe. Analysis of genomic characteristics and transmission routes of patients with confirmedSARS-CoV-2 in southern California during the early stage of the US COVID-19 pandemic.  JAMA Network Open 07-OCT-2020
AstraZeneca can profit after July 2021.  The company promised not to profit "during the pandemic" but reserves the right to declare the pandemic ended July 2021.
Mitigation measures work. Trends in COVID-19 incidence after implementation of mitigation measures - Arizona, January 22 - August 7, 2020.  MMWR 06-OCT-2020
COVID-19s lingering effects. Patient-reported outcome measures after COVID-19: a prospective cohort study. Eur Resp Jnl 02-OCT-2020
Is detectable plasma COVID RNA a significant finding?  SARS-CoV-2 RNA in plasma is associated with ICU admission & mortality in patients hospitalized with COVID-19Clin Infect Diseases 05-SEP-2020. 
Re-infection is possible.  COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing.  Clin Infect Diseases 25-AUG-2020.
Lymphopenia, ^D-Dimer, VTE, LMWH, Cytokine release syndrome, antibodies. The looming storm: Blood and cytokines in COVID-19,  Blood Reviews 18-AUG-2020
2 or 3 layers of T-shirt cloth can be as efficient as a medical mask. Performance of fabrics for home-made masks against the spread of COVID-19 through droplets: A quantitative mechanistic study.  Extreme Mechanics Letters 2020-OCT. 
The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 InfectionImmunogenetics 02-AUG-2020
Lack of nosocomial transmission to exposed inpatients and co-workers in an investigation of five SARS-CoV-2 infected healthcare workers.  Infect Ctrl & Hosp Epidem  Letter. 03-AUG-2020
Association between ABO blood groups and COVID-19 infection, severity an demise: A systematic review and meta-analysis  Infection, Genetics and Evolution 30-JUL-2020
Association between statewide school closure and COVID-19 incidence and mortality in the US.  JAMA  29-JUL-2020
Hand Sanitizers contaminated with Methanol: FDA recall to prevent methanol poisoning.  21-JUL-2020
Temperature in nursing home residents systematically tested for SARS-CoV-2 Jnl Am Med Dir Assn. JUL 2020; Nearly 75% of COVID-19 positive residents did not meet the fever threshold of 38°
Does a modified adhesive respirator improve the face seal for health care workers who previously failed a fit test?  A&A Pract.  JUN 2020.  Another use for fashion tape!
Estimating the effect of social distancing interventions on COVID-19 in the U.SPreprint, not yet peer-reviewed. 11-JUL-2020..  It turns out that closing schools & social distancing works.
Decontamination ad reuse of N95 filtering facemask respirators. AJIC JUL 2020  UV light and vaporized H2O2 look the most promising. 
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment Nature Communications 06-JUL-2020.  Wantai ELISA had the best specificity & sensitivity for IgG and IgM.
Clinical characteristics of patients w/ COVID-19 receiving emergency medical services in King County WA JAMA Network Open 08-JUL-2020. Current screening checklists may not be sensitive enough to identify COVID patients.
Transmission of SARS-CoV-2: an update of current literature.  Eur jnl clin microbiol & infect diseases 07-JUL-2020.  "Newer studies have highlighted the potential for alternative [not respiratory droplet] routes..."
Tocilizumab in patients with severe COVID-19: A single-center observational analysis. Jnl of Med Virology. 17-JUN-2020.  Fewer than 1/3 of patients with severe COVID given tocilzumab had clinical improvement within 14 days.
Visualizing the effectiveness of face masks in obstructing respiratory jetsPhysics of Fluids 30-JUN-2020.  Bandanas are NOT as effective as "well-fitted homemade masks with multiple layers..."
Oxford team begins vaccine trials in Brazil and South Africa to determine efficacy  BMJ News 29-JUN-2020
Social distancing alters the clinical course of COVID-19 in young adults: A comparative cohort studClin Infect Diseases 29-JUN-2020
Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results  Clin Microbiol & Infect  25-JUN-2020
COVID-19: Timing is critical for antibody tests, finds Cochrane review  BMJ 25-JUN-2020
Risk factors for 2019 novel coronarvirus disease (COVID-19) patients progressing to critical illness: a systematic review and meta-analysis.  Aging  24-JUN-2020
Comparison of epidemiological variations in COVID-19 patients inside and outside of China - A meta-analysis  Front Public Health  24-JUN-2020
What is the evidence to support the 2-metre social distancing rule to reduce COVID-19 transmission? CEBM. 22-JUN-2020
Persistent positivity and fluctuations of SARS-CoV-2 RNA in clinically-recovered COVD-19 patients  Jnl of Infect  20-JUN-2020
Identifying airborne transmission as the dominant route for the spread of COVID-19.  Proc Natl Acad Sci USA 13-JUN-2020
Top U.S. Coronavirus Hot Spots are all Indian Lands - New York Times 30-MAY-2020
Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic. Early release (not final version):  Emerging Infectious Diseases July 2020
AstraZeneca partners with Oxford University to product COVID-19 vaccine; The Guardian news article; 30-APR-2020

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial The Lancet  29-APR-2020

Updates on What ACS Reported: Emerging Evidences of COVID-19 with Nervous System Involvement ACS Chem Neurosci 28-APR-2020

Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens  Jnl Clin Microbiol  27-APR-2020

FDA issues Emergency Use Authorization permitting emergency usage of Stryker Sterizone VP4 Sterilizer with N95 Respirator Decontamination Cycle to decontaminate N95 or N95-equivalent respirators in hospital setting, enabling reuse by clinicians 

Quarantine measures reported to reduce incidence and mortality during COVID-19 pandemic (Cochrane)

Prevalence of gastrointestinal symptoms about 18% in patients with confirmed COVID-19

Clinical Characteristics of 3,062 COVID-19 Patients: A Meta-Analysis

SAR-CoV-2 viral shedding estimated to peak before or at onset of symptoms in patients with COVID-19.
FDA Emergency Use Authorization regarding B. Braun Space and Outlook Pumps 16-APR-2020
More on Chloroquine/Azithromycin.  And on Dr. Raoult.  Opinion/Commentary. Science Translational Medicine.

Loss of smell and taste a key symptom for COVID-19 cases

Humans, Viruses, and the Eye—An Early Report From the COVID-19 Front Line  JAMA Ophthalmology 31-MAR-2020 

Severe outcomes among patients with coronavirus disease 2019 - United States - Feb 12 - March 16, 2020 (CDC)

Surviving Sepsis Campaign Guidelines on the management of critically ill adults with coronavirus disease 2019  Critical Care Medicine 28-MAR-2020

COVID-19 Situation Reports (Johns Hopkins)

CDC Situation Summary

Maricopa County Public Health

COVID-19 Summaries / Broad View

Resource

Why use it?

National Institutes of Health, or UpToDate, or Dynamed, or British Medical Journal or Infectious Diseases Society of America

Clinical overviews; some identify evidence quality

Quickly find specific focus area (e.g., diagnosis)

Updates are noted/highlighted

Society guidelines (UpToDate) International coverage, listed by medical specialties & country.
CDC Situation Summary Information for Health Care Professionals
COVID-19 Information Portal (EBSCO) Global scope, leans toward government policy & news

COVID-19 Clinical Decision-Making

Resource

Why use it?

Physician's Guide + Resources (American College of Physicians) Current education on all clinical aspects of COVID-19. Updates are clearly posted. CME credit available
COVID Ready Communication Playbook (VitalTalk) JUN 2020 Has practical advice on how to talk with patients/families about difficult COVID-related topics.  Continuum of care.  Multiple languages.
A Composite Reference Standard for COVID-19 Diagnostic Accuracy Studies: A roadmap (CEBM, University of Oxford) Diagnosis support.  The group is developing a reference standard for diagnosis and aims to decrease the number of false negative rRT-PCRs
Guidelines (Elsevier) Clinical guidelines for therapy, labs, testing, PPE, ventilators
Treatment algorithms (BMJ Best Practice) Clinical decision support for suspected and confirmed COVID-19
Oxford COVID-19 Evidence Service (Univ. of Oxford Centre for Evidence-Based Medicine) Rapid reviews of primary care questions; updates noted.
Clinical Care FAQs - Your Questions Answered ECRI answers to questions from health care workers

COVID-19 Patient Populations

Resource Why Use It?
What are the risk factors and effectiveness of prophylaxis for venous thromboembolism in COVID-19 patients?  CEBM Review from University of Oxford COVID-19 Evidence Service Team. 10-JUL-2020
SARS-CoV-2/COVID-19: A primer for cardiologists Neth Heart Jnl  17-JUL-2020
Management of coexisting conditions in the context of COVID-19  (BMJ Best Practice) Regular updates are plainly identified.  Addresses broad range of conditions as more becomes known.
COVID-19 and Patients wth Cancer (Dynamed) Clinical decision support
COVID-19 and Pregnant Patients (Dynamed) Clinical decision support
COVID-19 and patients with CKD and ESRD (Dynamed) Clinical decision support
COVID-19 and Special Populations (Dynamed) Clinical decision support re: cancer, coagulopathies, CV disease, kidney disease, HIV infection, neurological conditions, pediatrics, & pregnancy.

COVID-19 literature: drink from the firehose

Resource

Why use it?

LitCOVID (National Library of Medicine) Updated every 24 hours as COVID-19-related articles are indexed in PubMed. Easily narrow focus to topics like transmission, case reports, diagnosis, forecasting, treatment.
Global literature on coronavirus disease (World Health Organization) Global perspective, easily narrow search by major subjects, type of study, language, and clinical focus.
PubMed COVID-19 Search (National Library of Medicine) Use this basic COVID-19 search strategy as a starting point for your own searches.