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All Things Covid-19: Signs & Symptoms / Diagnosis

Signs & Symptoms

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More than loss of taste and smell: burning watering eyes in coronavirus disease 19 (COVID-19) Clinical Microbiology and Infection 21-AUG-2020
Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network - United States, March-June 2020. MMWR 31-JUL-2020
Symptom profiles of a convenience sample of patients with COVID-19 - U.S., January - April 2020. MMWR 17-JUL-2020
Association of initial viral load in SARS-CoV-2 patients w/ outcome and symptoms. 

Am Jnl Pathology 03-JUL-2020.  Viral load was associated w/ shorter duration of symptoms prior to testing and shorter duration of hospital stay in New York city ED patients. Viral load not associated w/ admission to ICU.

COVID-19 patients presenting with afebrile acute abdominal pain

Clin Med Jnl (London) 27-APR-2020

Prevalence and Characteristics of Gastrointestinal Symptoms in Patients with SARS-CoV-2 Infection in the United States: A Multicenter Cohort Study.

Gastroenterology 22-APR-2020

Case-Fatality rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

JAMA March 23, 2020
Don't overlook digestive symptoms in patients with 2019 novel coronavirus disease

Clin Gastro & Hepatol  A case series of hospitalized patients with SARS-CoV-2 infection whose initial symptoms were gastrointestinal. (China)

A cured patient with 2019-nCoV pneumonia Am J Medicine  Case report, X-ray images
Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China JAMA  Case series; hospital-related transmission




Decline in SARS-CoV-2 antibodies after mild infection among frontline health care personnel in a multistate hospital network - 12 States, April-August 2020 MMWR 27-NOV-2020
Clinical Performance of the Point-of-Care Cobas Liat for Detection of SARS-CoV-2 in 20 Minutes: A Multicenter Study Jnl of Clin Microbiol, 25-NOV-2020
Differences in performance characteristics among four high-throughput assays for the detection of antibodies against SARS-CoV-2 using a common set of patient samples American Journal of Clinical Pathology 09-OCT-2020
The utility of repeat testing for COVID-19: Lab stewardship when the stakes are high.  There may be little benefit of repeat SARS-CoV-2 PCR testing within 7 days after a negative test in certain patients.  Infect Ctrl & Hosp Epi 03-AUG-2020
An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment.

Wantai ELISA had the best specificity & sensitivity for IgG and IgM.  Nature Communications 06-JUL-2020.

Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results Clin microbiol and infection  25-JUN-2020 (pre-print)

Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes

Preprint (not yet peer-reviewed) medRxiv 04-MAY-2020

Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens

Jnl Clin Microbiol 27-APR-2020

Asymptomatic SARS-CoV-2 infected case with viral detection positive in stool but negative in nasopharyngeal samples lasts for 42 days

Jnl Med Virology 24-APR-2020

Augmented Curation of Unstructured Clinical Notes from a Massive EHR System Reveals Specific Phenotypic Signature of Impending COVID-19 Diagnosis.  Mayo Clinic

Preprint (not yet peer reviewed) medRxiv 23-APR-2020

Loss of smell and taste a key symptom for COVID-19 cases

UK COVID symptom tracker 

Performance of VivaDiagTM COVID-19 IgM/IgG Rapid Test is inadequate for diagnosis of COVID-19 in acute patients referring to emergency room department

Jnl Medical Virology  30-MAR-2020
Report from the ASM COVID-19 International summit, 23 March 2020: Value of diagnostic testing for SARS-CoV-2/COVID-19 American Society for Microbiology
Novel Screening and Triage Strategy in Iran During Deadly COVID-19 Epidemic; Value of Humanitarian Teleconsultation Service Jnl Am Coll Radiol  March 24, 2020

Interim Guidance for Implementing Home Care of People Not Requiring Hospitalization for COVID-19 

CDC guidance for people coordinating home care & isolation of people with confirmed or suspected infection, including persons under investigation.  (Patients evaluated in an outpatient setting who do not require hospitalization and/or patients discharged home following hospitalization with confirmed infection.)

Evaluating and Testing Persons for COVID-19

CDC Criteria for lab tests, recommendations for specimen collection, patient priortization.

Preventing the Spread of Coronavirus Disease 2019 in Homes and Residential Communities

CDC Recommendations for household members, partners & caregivers in a non-healthcare setting exposed to (1) a patient with symptomatic or lab-confirmed COVID-19 or (2) a patient under investigation (PUI).

Information for Pediatric Healthcare Providers

CDC guidance on clinical presentation, treatment, prevention

Information for Healthcare Providers: COVID-19 and Pregnant Women

CDC FAQs re:transmission during pregnancy delivery, or breast milk, and infants, 

Discontinuation of In-Home Isolation for Immunocompromised Persons with COVID-19 

CDC guidance for immunocompromised & non-immunocompromised patients
Checklist to Prepare Physician's Offices for COVID-19 AAFP guidelines for ambulatory settings

Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics 

An algorithm to follow (The Lancet Respiratory Medicine)