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All Things Covid-19: Therapies / Management / Treatment

Therapies / Articles

Article Title

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Effect of bamlanivimab as monotherapy or in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical trial  JAMA 21-JAN-2021 Treatment with bamlanivimab and etesevimab combination therapy, but not bamlanivimab monotherapy, resulted in a reduction in SARS-CoV-2 log viral load at day 11 in patients with mild to moderate COVID-19.

Early high-titer plasma therapy to prevent severe COVID-19 in older adults.   

NEJM 06-JAN-2021

160 mild covid patients who received convalescent plasma within 72 hrs after onset of symptoms were 48% less likely to develop severe respiratory disease compared to patients receiving placebo.

Remdesivir for the Treatment of COVID-19 - Final Report NEJM 08-OCT-2020
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants and cell protectives against SARS-C0V-2 papain-like protease Jnl Biomolec Struct & Dnamics  29-JUN-2020
Emergency use Authorization for Potential COVID-19 Treatment. [Remdesivir] U.S. FDA News Release 01-MAY-2020

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial 

The Lancet 29-APR-2020
Rationale for Consideration of Statins for COVID-19 Patients Massachusetts General
More on Chloroquine / Azithromycin.  And on Dr. Raoult.  By Derek Lowe Opinion / Commentary  Science Translational Medicine 29-MAR-2020

The use of anti-inflammatory drugs in the treatment of people with severe Coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China

Clinical Immunology Review.  May 2020

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

NEJM Special Report 30-MAR-2020

Updated approaches against SARS-CoV-2  

Antimicrob Agents & Chemo "mini-review"

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Int Jnl Antimicrob Agents Small sample size, adult patients,  promising results
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib Jnl Microbiol Immunol Infect 

Therapies / Resources

Resource

Details

Assessment of Evidence for COVID-19-Related Treatments American Society of Health System Pharmacists (ASHP) Look for "Evidence Table" on the webpage.
BLAZE-1 Clinical Trial 2 monoclonal antibodies showed evidence of efficacy. From a Eli Lilly Press Release 07-OCT-2020.   Not peer reviewed.
Tocilizumab: drug vignette University of  Oxford EBM center. updated 05-AUG-2020
Ad-Hoc COVID-19 Treatment Team algorithms & protocols.   Yale University; color coded guidance sheets, from "non-severe"  to severe disease. Updated as reliable information emerges. 03-AUG-2020
COVID-19 Treatment University of Washington.  Includes educational  info & slide decks on all aspects of treatment.
Fact sheet for health care providers: Emergency use authorization of Remdesivir (GS-5734™) FDA Fact Sheet 01-MAY-2020
Evidence Table of COVID-19-Related [Drug] Treatments. American Society of Health-System Pharmacists 04-MAY-2020
A real-time dashboard of clinical trials for COVID-19 The Lancet; 24-APR-2020 graphic of trials 

BMJ Best Practice "Approach"

Brit Med Jnl. Approach to therapy from severe to mild cases, comorbidities, pregnant women & neonates

BMJ Best Practice "Treatment Algorithm"

Brit Med Jnl.  Algorithms for suspected & confirmed COVID-19 infection

BMJ Best Practice "Emerging Treatments"

Brit Med Jnl. 

BMJ Best Practices Complications

Brit Med Jnl. Known complications, their likelihoods, and time frames

COVID-19 Drug Therapy - Potential Options

Pharmacist Summary - Elsevier
COVID-19 Antiviral and Pharmacotherapy Recommendations  U of Nebraska Medical Center Pharmacy Recommendations

Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics 

The Lancet Respiratory Medicine Provides an algorithm to follow